Acute Tubular Necrosis
|Anatomy of the Kidney|
|Copyright © Nucleus Medical Media, Inc.|
- Lack of oxygen to kidney tissues from problems such as blood clots, surgical complications, severe dehydration, or heavy bleeding
- Exposure to toxic materials such as antibiotics, x-ray dyes, or anesthetics
- Blood transfusion
- Septic shock
- Low blood pressure
- Liver disease or damage
- Certain medications, such as aminoglycosides, amphotericin B, cyclosporine, or tacrolimus
- X-ray dye
- Blood transfusion reaction
Exposure or build up of toxic chemicals, such as:
- Crystals (uric acid, calcium phosphate)
- Change in urine output
- General swelling, fluid retention
- Nausea, vomiting
- Blood tests
- Urine tests
- Kidney biopsy
Family Doctor—American Academy of Family Physicians http://familydoctor.org
National Institute of Diabetes and Digestive and Kidney Diseases http://www.niddk.nih.gov
Health Canada http://www.hc-sc.gc.ca
Kidney Foundation of Canada http://www.kidney.ca
Acute tubular necrosis. EBSCO DynaMed website. Available at: http://www.ebscohost.com/dynamed. Updated June 14, 2010. Accessed November 1, 2012.
Choudhury D, Ahmed Z. Drug-associated renal dysfunction and injury. Nat Clin Pract Nephrol. 2006;2(2):80-91
Esson ML, Schrier RW. Diagnosis and treatment of acute tubular necrosis. Ann Intern Med. 2002;137(9):744-52.
Gill N, Nally JV Jr, Fatica RA. Renal failure secondary to acute tubular necrosis: Epidemiology, diagnosis, and management. Chest. 2005;128(4):2847-2863.
Musso CG, Liakopoulos V, Ioannidis I, Eleftheriadis T, Stefanidis I. Acute renal failure in the elderly: Particular characteristics. Int Urol Nephrol. 2006;38(3-4):787-793.
Tepel M, van der Giet M, Schwarzfeld C, Laufer U, Liermann D, Zidek W. Prevention of radiographic-contrast reductions in renal function by acetylcysteine. N Engl J Med. 2000;343(3):1448-1457.
- Reviewer: Adrienne Carmack, MD
- Review Date: 05/2015 -
- Update Date: 05/11/2013 -